Journal: Cell Communication and Signaling : CCS

Article Title: Marine trichodermamide B inhibits prostate cancer progression via catalase inhibition-induced apoptosis

doi: 10.1186/s12964-026-02737-y

Figure Lengend Snippet: Trichodermamide B (TRH2) affects prostate cell cycle and apoptosis in prostate cancer cells. A & B Effect of TRH2 on the cell cycle distribution of LNCaP cells. C & D Effect of TRH2 on the cell cycle distribution of PC-3 cells. E & F The protein expression of Cyclin A2 in LNCaP cells. G & H The protein expression of Cyclin A2 in PC-3 cells. I & J Effect of TRH2 on apoptosis in 22Rv1 cells. K & L Effect of TRH2 on apoptosis in PC-3 cells. * P <0.05, ** P <0.01 vs control

Article Snippet: After treatment with either DMSO (0.1%, v/v) or TRH2 (8 μM) for 48 h, cells were harvested and proteins were extracted and analyzed according to the instructions of the Human Apoptosis Array Kit (Cat# ARY009, R&D Systems).

Techniques: Expressing, Control

Journal: Cell Communication and Signaling : CCS

Article Title: Marine trichodermamide B inhibits prostate cancer progression via catalase inhibition-induced apoptosis

doi: 10.1186/s12964-026-02737-y

Figure Lengend Snippet: Trichodermamide B (TRH2) alters the ultrastructure of prostate cancer cells and modifies the expression of apoptosis-related proteins. A Morphology of normal LNCaP cells under the transmission electron microscope. B & C Morphological changes in LNCaP cells treated with TRH2 under transmission electron microscopy. D & E Effect of TRH2 on the expression of apoptosis-related proteins in LNCaP cells. F & G Effect of TRH2 on the expression of apoptosis-related proteins in PC-3 cells

Article Snippet: After treatment with either DMSO (0.1%, v/v) or TRH2 (8 μM) for 48 h, cells were harvested and proteins were extracted and analyzed according to the instructions of the Human Apoptosis Array Kit (Cat# ARY009, R&D Systems).

Techniques: Expressing, Transmission Assay, Microscopy, Electron Microscopy